The Investigation on the Retention of Cervix Uteri and ...

[Abstract]

Objective: To investigate the value of retention of cervix uteri and essentiality ofappendectomy in the epithelial ovarian cancer (EOC). Methods: The clinical data of 145patients were analyzed retrospectively, which were in the Guizhou Provincical People?s Hospital and the Affiliated hospital of Zunyi Medical College from 1999 to 2008. The metastatic circumstance about clinical pathological data in omentum, appendix and cervix uteri were specifically analyzed according to international federation of obstetrics and gynecology (FIGO) stage, pathological type, pathological grade. The expression of VEGF-C and MMP-9 were detected by Streptavidin Peroxidase (SP) method in 30 cases of EOC and 20 benign ovarian tumor and they were analyzed in omentum, appendix and cervix uteri,which were in the Affiliated hospital of Zunyi Medical College from 2003 to 2008. Results:1. The analysis of clinical pathological data: There were 63 cases omentum metastases in 118 cases omentumectomy and it?s metastases rate was 53.39%. The metastases rate of omentum in serous cystadenocarcinoma was higher than that in mucous cystoadenocarcinoma (P < 0.05) .The metastases rate of omentum in histological grade step up from well differentiated to poorly differentiated gradually (P<0.05). There were 16 cases appendix metastases in 57 cases appendectomy and it?s metastases rate was 28.07%. There were no appendix metastases in 19 cases early EOC patients. There were 16 cases appendix metastases in 38 cases advanced EOC patients and it?s metastases rates were 42.11%. The metastatic circumstance of EOC in appendix was closely correlated with FIGO stage. But it was not correlated with histological type and histological grade (P>0.05). There were no cervix uteri metastases cases in 134 cases total abdominal hysterectomy. 2. The positive expression of VEGF-C and MMP-9 protein were found in tumor cell intracytoplasm. The positive expression of MMP-9 protein was also found in some cellula intersitialis. The expression of VEGF-C and MMP-9 in the tissues of EOC were statistically different from those in benign ovarian tumor (P< 0.05). But they were not correlated with the FIGO stage, histological type, and histological grade (P>0.05). 3. The expression of VEGF-C and MMP-9 in metastases of omentum and appendix were not statistically different from those in the tissues of EOC (P>0.05) .The expression of VEGF-C and MMP-9 in normal mentum, appendix and cervix uteri were statistically different from those in the tissues of EOC(P<0.05). 4. The expression ofMMP-9 and VEGF-C were not correlated with each other. Conclusoins: 1. The EOC wasnot easily metastasize to cervix uteri, so it is reasonable alternative to retain cervix uteri in young patients, early stage of EOC and difficult surgery in advanced stage. 2. The metastatic circumstance of EOC in appendix was closely correlated with FIGO stage. But it was not correlated with histological type and histological grade. According to goals of treatment and reducing perioperative complications, we claimed the appendix may be retained in early stage and be properly removed in advanced stage. 3. VEGF-C and MMP-9 were highly expressed in primary and metastatic ovarian carcinoma, and might play an important role in the onset and progression of ovarian malignant tumor. VEGF-C and MMP-9 were less expressed in cervix uteri, that presumed EOC was not easily metastasize to cervix uteri, then it is reasonable alternative to retain cervix uteri. 4. The over expression of VEGF-C and MMP-9 might be the molecular marker for the infestation and metastasis of epithelial ovarian carcinoma.

Title: The Investigation on the Retention of Cervix Uteri and Appendectomy of the Epithelial Ovarian Cancer

Category: Tumor Research

Filename: The Investigation on the Retention of Cervix Uteri and Appendectomy of the Epithelial Ovarian Cancer.pdf

Pages: 102

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